Prior to signing with Interscope, 50 engaged in dispute with rapper Ja Rule and his label Murder Inc. Reports initially claimed that Jackson believed a friend robbed Ja Rule of his jewelry and that Ja had accused him of setting it up. However, Ja Rule claimed the conflict started during a video shoot in Queens when Jackson did not like seeing him "getting so much love" from the neighborhood.
In March 2000, Jackson had an altercation at The Hit Factory in New York with Murder Inc. associates. He was treated for three stitches after receiving a stab wound Rapper Black Child claimed responsibility for the stabbing, stating that he acted in self-defense because he thought someone reached for a gun.
Since then, Black Child publicly insulted 50 Cent twice in "There's a Snitch in the Club", and "You the Wanksta". Ja, too, responded with an entire album's worth of material aimed at the Unit titled Blood In My Eye. The album was a commercial and critical flop. Eminem, Dr. Dre, Obie Trice, D12, DMX, and Busta Rhymes also became involved and released tracks which insulted Ja Rule.
The crux of the beef, however, took place when Ja Rule released the successful single "New York" featuring Jadakiss and Fat Joe in which Ja Rule took subliminal shots at 50 Cent. This single prompted 50 Cent to enter a feud with the two featured artists, deeming them guilty by association. The trio came under fire in "Piggy Bank," each being depicted in the song's animated music video.
In May 2011, it was confirmed that both Ja Rule and 50 Cent squashed the feud. Ja Rule said "I’m cool. We ain’t beefing no more. We’ll never collaborate. That’s just what it is. You don’t have to be at war with somebody, but it’s also kind of like U.S. and another country that they may not get along with. We don’t gotta go to war, but we’re not friends either. But we can coincide inside of a world. He’s doing him, and he’s not thinking about me, and I’m doing me and I’m not thinking about him."
Ja Rule has admitted losing his battle with 50. In September 2013, in an interview with Angie Martinez, both Ja Rule and Murder Inc. CEO Irv Gotti acknowledged the beef not only took a toll on Ja Rule's career, but damaged Murder Inc as a music label.
New York - Ja Rule, Fat Joe & Jadakiss
Clap Back - Ja Rule
Black Ferrari (The Real Wanksta) - Black Child
I Smell Pussy - G-Unit
Order of Protection - G-Unit
Shit Hits The Fan - Eminem, Dr. Dre & Obie TriceHail Mary - Eminem, 50 Cent & Busta Rhymes