Kanye West was one of the earliest adopters of T-Pain's sound, and was actually able to work with Pain directly on much of his music. The first step came with the singer's hook on "Good Life", which became a massive hit for Kanye, peaking at number 7 on the Hot 100.
Following his breakup with Alexis Phipher and the death of his mother, Donda West, Ye decided to follow up his arena rap opus, Graduation, with a more understated, emotionally fragile album, 808s & Heartbreak. To illustrate the pain he was going through at the time, he decided to color his voice with auto-tune, and he brought T-Pain in to the studio to help him write.
While the sessions with Pain were a bit rocky (at one point there was actually a diss track recorded by Ye, where he jokingly told the singer to step his game up), the auto-tuned crooner landed a writing credit on "RoboCop", and his influence can be heard throughout the album.
While Ye has not done another whole project incorporating the synthesized vocal effect, he's never stopped using it, allowing him to perform (what may be) the first auto-tune solo on "Runaway," and to reach the notes on recent melodic records, "Only One" and "FourFiveSeconds".